In vitro cell cultures, cloning

Our group routinely uses immortalised cell cultures to reduce animal sacrifices and to study precise molecular mechanisms. We also use primary neuronal astrocyte, neuronal and tanycytic cell cultures to study the mechanisms of cortical and hypothalamic TH signalling.

The main tool for our transfection experiments on both primary and immortalised cell cultures is our proprietary library of almost a thousand DNA constructs. These constructs form the basis of many of our transgenic animal models (e.g. the THAI mouse) aswell.