Mania model

Purinergic dysfunction are involved in the pathological process of mania and depression, but the essential association is not fully understood. The activation of the purinergic P2X7 receptor (P2X7R) plays a central role in inflammation, microglia activation and IL-1β release and activates NLRP3 inflammasome. We investigated whether the d-amphetamine (AMPH) has an inflammatory profile, and the P2X7R has an effect via IL-1β in this model.

We analysed the modulatory effects of the P2X7R antagonist, JNJ 47965567, on behaviour, tissue cytokines, monoamines, brain-derived neurotrophic factor (BDNF) and plasma purine levels in a sub chronic-d-amphetamine-induced mania model in wild-type and IL-1αβ-double knockout (IL-1αβKO) mice.