Our study on microglia in acute slices on BioRxiv
With the shared first authorship of Péter Berki, Csaba Cserép and Zsuzsanna Környei, with Ádám Dénes as the corresponding author, our study titled: „Microglia undergo rapid phenotypic transformation in acute brain slices but remain essential for neuronal synchrony” is deposited on BioRxiv.
With the shared first authorship of Péter Berki, Csaba Cserép and Zsuzsanna Környei, with Ádám Dénes as the corresponding author, our study titled: „Microglia undergo rapid phenotypic transformation in acute brain slices but remain essential for neuronal synchrony” is deposited on BioRxiv ().
This work describes how complex signalling mechanisms drive robust and time-dependent microglial phenotype changes after cutting of acute ex vivo brain slices, which represent a “workhorse” model for studying the central nervous system (CNS) from nanoscale events to complex circuits. The results confirm that microglia are inherent modulators of complex neuronal networks, and their specific actions are indispensable to maintain neuronal network integrity and activity ex vivo. These findings could facilitate new lines of research resulting in improved ex vivo methodologies and a better understanding of microglia-neuron interactions both in physiological and pathological conditions.