Morphometry, image analysis

Sunday, 20 March, 2022

Postmenopausal hypertrophy of human kisspeptin neurons


The large number of the immersion-fixed tissue specimens enables the morphometric studies of neurons to establish sex differences and aging-related changes of the human hypothalamic kisspeptin system. The example in the figure reveals a significant sex difference in the size (mean profile area) of kisspeptin neurons in the human infundibular nucleus of middle-aged males vs. females. The increased cell size in postmenopausal women results from the absence of estrogens.


Hrabovszky et al., Front Endocrinol (Lausanne): 2:80