Our work contributes to the understanding of the molecular-level phenomenon of tolerance that occurs with regular cannabis use. Benjámin Barti, a highly talented PhD student of the group, was the lead author of the publication. The credit also goes to Beni for the artistic depiction of a pyramidal neuron featured on the cover page. The rainbow-coloured dots represent cannabinoid receptors on the surface of an incoming axon giving an inhibitory synapse on the pyramidal neuron.